530581 Cellular Biochemistry  Prof. Sebastian Springer

(Prof. Springer's home page, contact details)

 

The location of the course is Seminar 1 in Research II. It takes place at 11:15 to 12:30 every Friday in Seminar I, Research II.

 

Topic

In the fall of 2009, the course will focus on the biochemistry and cell biology of antigen presentation, that is, the defence mechanism of the mammalian immune system against infection with viruses and intracellular bacteria, which also plays a role in cancer and transplantation.

Antigen presentation will be explored from the point of view of the proteins involved: their structure, function, and intracellular fate.

 

How the course goes

There are thirteen classes. Each class is opened by a prepared 15 minute intro talk by a student on the assigned reading material.  

 

Syllabus of the course:

 

Class

Date

Quiz

Intro talk

Content

1

Sep 4

 

–

Introduction; abstracting and presenting information

 

Sep 11

 

 

No class

2

Sep 18

 

S. Springer

Protein degradation (general) and the ubiquitin system; distribution of the presentations

3

Sep 25

 

N. Tomic

Proteasome

4

Oct 2

 

M. Moravek

ER-associated degradation

5

Oct 9

 

M. Beber

The immune system; antigen presentation through MHC class I molecules

6

Oct 16

Ã

S. Montealegre

Structure of MHC class I molecules, and peptide binding to them

7

Oct 23

 

M. Moravek

DRiPs, epitope generation in the cytosol, and the immunoproteasome

8

Oct 30

 

S. Mehandziska

Transport of peptides in the ER, and proteolysis in the ER

9

Nov 6

 

–

MHC class I quality control in the secretory pathway

10

Nov 13

Ã

S. Mehandziska

Crosspresentation of exogenous peptides on MHC class I

11

Nov 20

 

S. Montealegre

Endocytosis and cell surface quality control of class I molecules

12

Nov 27

 

N. Tomic

Viral and bacterial escape from MHC class I presentation

13

Dec 4

Ã

M. Beber

MHC class II molecules

 

Grading:

Presence and participation 20% - Quizzes 30% - Final 30% - Introductory talk 20%

 

Materials:

Comprehension questions

Additional papers

Advice for preparing the introductory presentations

Advice on obtaining additional scientific information

Link to the Springer MHC Wiki: http://springerwiki.jacobs-university.de/MHCwiki/Wikka/wikka.php?wakka=LiteratureOverview