Immunology 520322 Spring 2010

Sebastian Springer, Instructor of Record (email, lab home page, my own research)

 

The location of the course is Seminar 1 in Research II. It takes place at 15:45 - 17:00, Thursdays and Fridays. There are no classes on March 25 and March 26. The class on May 14 consists of a quiz only.

 

 

Structure of the course

The course has 25 classes. There will be 15 taught lecture classes and 9 presentation classes.

 

The Lecture Classes are presentations by Prof. Springer about immunological basics. Use the classes to answer the comprehension questions which will come up in the quizzes and the final exam. It is expected that you prepare for the classes by reading the assignments; there is a grade component for attendance and oral participation. 

 

The Presentation Classes consist of one paper presentation by a student (or a team of students). Papers are selected by the instructor (see the table below). Presenting students meet with the instructor one week before the presentation date with a finished presentation and specific questions. This meeting is part of the grade (see below). The presentation lasts 45 minutes, plus 15 minutes discussion.

 

Schedule of Classes:

 

Class #

Date

Type of class

Topic or Paper

Reading Assignment
to be read before class

1

Feb 04

Lecture

Introduction to the course

No prior reading.

2

Feb 05

Lecture

Overview and fundamental function of the immune system: Pathogenicity - cells and organs of the immune system - innate and adaptive immune system - the course of an immune response

Janeway chapter 1 (provided in the Materials)

3

Feb 11

Lecture

The Innate Immune System

Janeway chapter 2 (provided in the Materials)

4

Feb 12

Paper presentation

Prof. Springer

Flo, Aderem, et al.:  Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432 (2004), p. 917-921. Editorial: Nature 432, p. 811-813

Additional reading:  Goetz, Strong, et al., Molecular Cell 10 (2002), p. 1033-1043.

The paper

5

Feb 18

Lecture

Antigen recognition by antibodies and T cell receptors

Janeway chapter 3

6

Feb 19

Quiz 1 and Lecture

Immunological Methods

Janeway appendix 1

7

Feb 25

Lecture

Antigen presentation through MHC class I molecules

Janeway chapters 3 and 5, and see Materials

8

Feb 26

Paper presentation
Preparation Meeting:
Feb.18, after class

Neijssen, Neefjes, et al.: Cross-presentation by intercellular peptide transfer through gap junctions. Nature 434 (2005), p. 83-88. Editorial: Heath and Carbone, Nature 434 (2005), p. 27.

The paper

9

Mar 04

Lecture

Antigen presentation through MHC class II and CD1 molecules

Janeway chapters 3 and 5, and see Materials

10

Mar 05

Paper presentation

Preparation Meeting:
Feb. 25, after class

Mattner, Bendelac, et al.: Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434 (2005), p. 525-529.

Additional Reading: Zhou, Bendelac, et al., Science 306 (2004), p.1786-9

The paper

11

Mar 11

Lecture

The early life history of lymphocytes, and the development of their receptors

Janeway chapters 4 and 7

12

Mar 12

Paper presentation

Preparation Meeting:
March 4, after class

Anderson, Mathis, et al.: Projection of an immunological self shadow within the thymus by the aire protein. Science 298 (2002), p. 1395-1401. Editorial: Science 298 (2002), p. 1348.

The paper

13

Mar 18

Quiz 2 and Lecture

The course of an immune response, and the formation of immunological memory Disease: Plague

Janeway chapters 8 and 10

14

Mar 19

Paper presentation

Preparation Meeting:
March 11, after class

Chang, Reiner, et al.: Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses. Science 315 (2007), p. 1687.

The paper

15

Apr 08

Lecture

Subversion of the immune response by bacteria and viruses

Review articles in the Materials

16

Apr 09

Lecture

Tolerance, transplantation, and autoimmunity - Disease: SLE

Janeway chapter 14

17

Apr 15

Paper presentation

Preparation Meeting:
April 8, after class

Groh, Spies, et al.: Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc. Natl. Acad. Sci 100 (2003), 9452-9457.

The paper

18

Apr 16

Quiz 3 and Lecture

Immunoprivileged sites, and immunology of the brain – Disease: Multiple Sclerosis

Reviews (see Materials)

19

Apr 22

Presentation

Preparation Meeting:
April 15, after class

Heppner, Aguzzi, et al.: Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nature Medicine 2 (2005), p. 146.

The paper

20

Apr 23

Lecture

Parasites, antiparasitic immune response, and allergy; the mucosal immune system – Disease: allergy

Janeway chapter 13; and see materials

21

Apr 29

Lecture

Diseases: AIDS and Cancer

Janeway chapters 12 (AIDS) and 15 (Tumors), specific sections only; and see Materials

22

Apr 30

Presentation

Preparation Meeting:
April 22, after class

Koebel, Schreiber, et al.: Adaptive immunity maintains occult cancer in an equilibrium state. Nature 450 (2007), p. 903.

The paper

23

May 6

Lecture

Vaccine design

Janeway chapter 15 sections 15.19-15.40, and reviews in the Materials

24

May 7

Presentation

Preparation Meeting:
April 29, after class

Barouch, Letvin, et al.: Eventual  AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T  lymphocytes.  Nature 415 (2002), p. 335-339

Background: Barouch et  al., Science 290 (2000), p. 486-492

Review: Barouch, J.Path. 208 (2006), p. 283

The paper

25

May 14

Quiz 4 only

 

 

Presentations

 

Materials

 

Quizzes and Final Exam

 

Books and other sources of information:

 

Grading and absence policies